Abstract
A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC₅₀ value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / pharmacology*
-
Arisaema / chemistry*
-
Breast Neoplasms / drug therapy
-
Breast Neoplasms / pathology
-
Cell Line, Tumor
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry*
-
Drugs, Chinese Herbal / pharmacology*
-
Ethnicity
-
Female
-
Humans
-
Limonins / analysis*
-
Limonins / chemical synthesis
-
Limonins / chemistry*
-
Limonins / isolation & purification
-
Limonins / pharmacology
-
Magnetic Resonance Imaging
-
Ovarian Neoplasms / drug therapy
-
Ovarian Neoplasms / pathology
-
Piperidines / chemical synthesis*
-
Piperidines / chemistry
-
Piperidines / isolation & purification
-
Piperidines / pharmacology*
-
Rhizome / chemistry
Substances
-
(-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl)piperidine
-
6-deacetylnimbin
-
Alkaloids
-
Antineoplastic Agents
-
Drugs, Chinese Herbal
-
Limonins
-
Piperidines
-
28-deoxonimbolide
-
nimbin