Effect of deprenyl on free radical oxidation in rat brain during immobilization stress

Bull Exp Biol Med. 2009 Dec;148(6):856-8. doi: 10.1007/s10517-010-0835-1.

Abstract

Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxidatively modified proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Female
  • Free Radicals / metabolism*
  • Lipid Peroxidation / drug effects
  • Male
  • Monoamine Oxidase / metabolism
  • Oxidation-Reduction / drug effects
  • Rats
  • Restraint, Physical*
  • Selegiline / pharmacology*
  • Stress, Physiological / physiology

Substances

  • Enzyme Inhibitors
  • Free Radicals
  • Selegiline
  • Monoamine Oxidase