Abstract
Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acids / chemistry*
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Biocompatible Materials / chemistry
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Capsules / chemistry*
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Cell Line, Tumor
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Drug Carriers / chemistry*
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Humans
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Hydrogen-Ion Concentration
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Kinetics
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Paclitaxel / administration & dosage
Substances
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Acids
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Biocompatible Materials
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Capsules
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Drug Carriers
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Paclitaxel