A new neuroprotective bakkenolide from the rhizome of Peatasites tatewakianus

Zhen-Liang Sun; Gang-Long Gao; Jian-Ying Luo; Xue-Li Zhang; Ming Zhang; Jing Feng

doi:10.1016/j.fitote.2010.11.020

A new neuroprotective bakkenolide from the rhizome of Peatasites tatewakianus

Fitoterapia. 2011 Apr;82(3):401-4. doi: 10.1016/j.fitote.2010.11.020. Epub 2010 Nov 25.

Authors

Zhen-Liang Sun¹, Gang-Long Gao, Jian-Ying Luo, Xue-Li Zhang, Ming Zhang, Jing Feng

Affiliation

¹ Branch Hospital in Fengxian of Shanghai No 6 People’s Hospital, Shanghai, PR China.

PMID: 21111792
DOI: 10.1016/j.fitote.2010.11.020

Abstract

Constituents of the fruits of Peatasites tatewakianus were investigated. A new compound, namely bakkenolide-VI (1), was isolated. The structures was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties. The neuroprotective activity of the new compound was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults.

MeSH terms

Cell Culture Techniques
Fruit
Glucose / deficiency
Molecular Structure
Neurons / drug effects*
Neuroprotective Agents / pharmacology*
Oxidative Stress / drug effects
Oxygen / metabolism
Petasites / chemistry*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Rhizome / chemistry
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Spectrum Analysis / methods

Substances

Neuroprotective Agents
Plant Extracts
Sesquiterpenes
bakkenolide VI
Glucose
Oxygen