SIRT3 in calorie restriction: can you hear me now?

Carlos Sebastian; Raul Mostoslavsky

doi:10.1016/j.cell.2010.11.009

SIRT3 in calorie restriction: can you hear me now?

Cell. 2010 Nov 24;143(5):667-8. doi: 10.1016/j.cell.2010.11.009.

Authors

Carlos Sebastian¹, Raul Mostoslavsky

Affiliation

¹ The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, 02114, USA.

PMID: 21111225
DOI: 10.1016/j.cell.2010.11.009

Abstract

Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding