The existence of across-notation automatic numerical processing of two-digit (2D) numbers was explored using size comparisons tasks. Participants were Arabic speakers, who use two sets of numerical symbols—Arabic and Indian. They were presented with pairs of 2D numbers in the same or in mixed notations. Responses for a numerical comparison task were affected by decade difference and unit-decade compatibility and global distance in both conditions, extending previous findings with Arabic digits (Nuerk, Weger, & Willmes, 2001). Responses for a physical comparison task were affected by congruency with the numerical size, as indicated by the size congruency effect (SiCE). The SiCE was affected by unit-decade compatibility but not by global distance, thus suggesting that the units and decades digits of the 2D numbers, but not the whole number value were automatically translated into a common representation of magnitude. The presence of similar results for same- and mixed-notation pairs supports the idea of an abstract representation of magnitude.