Automation of labelling of Lipiodol with high-activity generator-produced 188Re

Nicolas Lepareur; Valérie Ardisson; Nicolas Noiret; Eveline Boucher; Jean-Luc Raoul; Bruno Clément; Etienne Garin

doi:10.1016/j.apradiso.2010.11.001

Automation of labelling of Lipiodol with high-activity generator-produced 188Re

Appl Radiat Isot. 2011 Feb;69(2):426-30. doi: 10.1016/j.apradiso.2010.11.001. Epub 2010 Nov 12.

Authors

Nicolas Lepareur¹, Valérie Ardisson, Nicolas Noiret, Eveline Boucher, Jean-Luc Raoul, Bruno Clément, Etienne Garin

Affiliation

¹ Service de Médecine Nucléaire, Centre Régional de Lutte Contre le Cancer Eugène Marquis, CS 44229, 35042 Rennes, France. n.lepareur@rennes.fnclcc.fr

PMID: 21106381
DOI: 10.1016/j.apradiso.2010.11.001

Abstract

This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol ((188)Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Automation, Laboratory
Ethiodized Oil / chemistry*
Isotope Labeling / methods*
Radioisotopes*
Radiopharmaceuticals / chemical synthesis*
Rhenium*

Substances

Radioisotopes
Radiopharmaceuticals
Rhenium
Ethiodized Oil