Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives

Chem Commun (Camb). 2011 Jan 7;47(1):559-61. doi: 10.1039/c0cc04754f. Epub 2010 Nov 23.

Abstract

This manuscript illustrates that the geometric arrangement of protein-binding groups around a ruthenium(II) core leads to dramatic differences in cytochrome c (cyt c) binding highlighting that it is possible to define synthetic receptors with shape complementarity to protein surfaces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,2'-Dipyridyl / analogs & derivatives*
  • 2,2'-Dipyridyl / chemistry
  • Binding Sites
  • Coordination Complexes
  • Cytochromes c / chemistry*
  • Cytochromes c / metabolism
  • Models, Molecular
  • Molecular Structure
  • Surface Properties

Substances

  • Coordination Complexes
  • tris(2,2-bipyridine)-ruthenium(II)
  • 2,2'-Dipyridyl
  • Cytochromes c