A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis

Chem Commun (Camb). 2011 Jan 14;47(2):788-90. doi: 10.1039/c0cc04306k. Epub 2010 Nov 22.

Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Halogens / chemistry
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Ketones / chemistry
  • Magnesium / chemistry

Substances

  • Halogens
  • Indoles
  • Ketones
  • Magnesium