Inhibition of ornithine-decarboxylase produced by S(+) and R(-) ibuprofen in rats

Pharmacol Res. 1990 Mar-Apr;22(2):97-102. doi: 10.1016/1043-6618(90)90705-i.

Abstract

The differences between the S(+) and R(-) ibuprofen enantiomers in anti-inflammatory activity were assayed by measuring the release of 14CO2 in rats treated with labelled 14COOH-ornithine. Furthermore we investigated in vitro the inhibitory activity on ornithine-decarboxylase and the anti-inflammatory activity of R(-) and S(+) ibuprofen by using the carrageenin-induced paw oedema test in the rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Dioxide / metabolism
  • Carrageenan
  • Edema / chemically induced
  • Edema / drug therapy
  • Escherichia coli / enzymology
  • Ibuprofen / pharmacology*
  • Injections, Intraperitoneal
  • Male
  • Ornithine Decarboxylase Inhibitors*
  • Rats
  • Rats, Inbred Strains
  • Stereoisomerism

Substances

  • Ornithine Decarboxylase Inhibitors
  • Carbon Dioxide
  • Carrageenan
  • Ibuprofen