Abstract
The differences between the S(+) and R(-) ibuprofen enantiomers in anti-inflammatory activity were assayed by measuring the release of 14CO2 in rats treated with labelled 14COOH-ornithine. Furthermore we investigated in vitro the inhibitory activity on ornithine-decarboxylase and the anti-inflammatory activity of R(-) and S(+) ibuprofen by using the carrageenin-induced paw oedema test in the rat.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbon Dioxide / metabolism
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Carrageenan
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Edema / chemically induced
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Edema / drug therapy
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Escherichia coli / enzymology
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Ibuprofen / pharmacology*
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Injections, Intraperitoneal
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Male
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Ornithine Decarboxylase Inhibitors*
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Rats
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Rats, Inbred Strains
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Stereoisomerism
Substances
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Ornithine Decarboxylase Inhibitors
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Carbon Dioxide
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Carrageenan
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Ibuprofen