Lab-on-a-chip for the isolation and characterization of circulating tumor cells

Tim Stakenborg; Chengxu Liu; Olivier Henry; Ciara K O'Sullivan; Christian Fermer; Tina Roeser; Marion Ritzi-Lehnert; Sigfried Hauch; Elin Borgen; Nadja Laddach; Liesbet Lagae

doi:10.1109/IEMBS.2010.5627655

Lab-on-a-chip for the isolation and characterization of circulating tumor cells

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:292-4. doi: 10.1109/IEMBS.2010.5627655.

Authors

Tim Stakenborg¹, Chengxu Liu, Olivier Henry, Ciara K O'Sullivan, Christian Fermer, Tina Roeser, Marion Ritzi-Lehnert, Sigfried Hauch, Elin Borgen, Nadja Laddach, Liesbet Lagae

Affiliation

¹ Imec, SSET-FNS, Kapeldreef 75, 3001 Heverlee, Belgium. tim.stakenborg@imec.be

PMID: 21096963
DOI: 10.1109/IEMBS.2010.5627655

Abstract

A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single platform.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Separation / instrumentation*
Cell Separation / methods
Cytophotometry / instrumentation
Cytophotometry / methods
DNA, Neoplasm / isolation & purification
Humans
Lab-On-A-Chip Devices*
Neoplasms / blood*
Neoplasms / genetics
Neoplasms / pathology
Neoplastic Cells, Circulating*
Polymerase Chain Reaction / instrumentation
Polymerase Chain Reaction / methods

Substances

DNA, Neoplasm