Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives

Gabin Mwande Maguene; Jouda Jakhlal; Melissa Ladyman; Aurélie Vallin; Dimby Andrianina Ralambomanana; Till Bousquet; Jeanne Maugein; Jacques Lebibi; Lydie Pélinski

doi:10.1016/j.ejmech.2010.10.004

Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives

Eur J Med Chem. 2011 Jan;46(1):31-8. doi: 10.1016/j.ejmech.2010.10.004. Epub 2010 Nov 20.

Authors

Gabin Mwande Maguene¹, Jouda Jakhlal, Melissa Ladyman, Aurélie Vallin, Dimby Andrianina Ralambomanana, Till Bousquet, Jeanne Maugein, Jacques Lebibi, Lydie Pélinski

Affiliation

¹ Université Lille Grand Nord, Université de Lille 1, Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, ENSCL, B.P. 108, 59652 Villeneuve d'Ascq, France.

PMID: 21094564
DOI: 10.1016/j.ejmech.2010.10.004

Abstract

In this work we reported the synthesis and evaluation of Mycobacterium tuberculosis activities in vitro of a series of twenty five ferrocenyl derivatives: ferrocenyl amides derived from nicotinamide and pyrazinamide, ferrocenyl pyridinyl, quinolyl and acridinylhydrazones. In particular ferrocenyl acylhydrazones 7 and 8 and ferrocenylquinoxaline amide 57 showed interesting antimycobacterial activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Ferrous Compounds / chemical synthesis*
Ferrous Compounds / chemistry
Ferrous Compounds / pharmacology*
Metallocenes
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Niacinamide / chemistry
Pyrazinamide / chemistry

Substances

Anti-Bacterial Agents
Ferrous Compounds
Metallocenes
Niacinamide
Pyrazinamide
ferrocene