14-3-3 proteins fine-tune plant nutrient metabolism

FEBS Lett. 2011 Jan 3;585(1):143-7. doi: 10.1016/j.febslet.2010.11.025. Epub 2010 Nov 19.

Abstract

14-3-3 Proteins regulate many cellular processes by binding to phosphorylated proteins. Previous findings suggest a connection between three 14-3-3 isoforms and plant nutrient signaling. To better understand how these 14-3-3s regulate metabolism in response to changes in plant nutrient status, putative new targets involved in nitrogen (N) and sulfur (S) metabolisms have been identified. The interactions between these 14-3-3s and multiple proteins involved in N and S metabolism and altered activity of the target proteins were confirmed in planta. Using a combination of methods, this work elucidates how 14-3-3s function as modulators of plant N and S metabolic pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 14-3-3 Proteins / genetics
  • 14-3-3 Proteins / metabolism*
  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / growth & development
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Blotting, Western
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Plant
  • Hydroponics
  • Immunoprecipitation
  • Metabolic Networks and Pathways*
  • Molecular Sequence Data
  • Mutation
  • Nitrogen / metabolism
  • Phosphates / metabolism
  • Plants, Genetically Modified
  • Potassium / metabolism
  • Protein Binding
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • RNA Interference
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sulfur / metabolism

Substances

  • 14-3-3 Proteins
  • 14-3-3chi protein, Arabidopsis
  • 14-3-3kappa protein, Arabidopsis
  • Arabidopsis Proteins
  • Phosphates
  • Protein Isoforms
  • Sulfur
  • Nitrogen
  • Potassium