Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)

J Biomater Sci Polym Ed. 2011;22(17):2357-67. doi: 10.1163/092050610X539541.

Abstract

Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by (1)H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

Keywords: NIPAAM; RADIO-OPACITY; THERMO-RESPONSIVE POLYMERS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Acrylamides / chemistry
  • Animals
  • Calorimetry, Differential Scanning
  • Cell Survival
  • Contrast Media / chemical synthesis*
  • Contrast Media / chemistry*
  • Iodobenzoates / chemistry
  • Mice
  • Molecular Structure
  • Molecular Weight
  • Polymers / chemical synthesis*
  • Polymers / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • Transition Temperature
  • X-Rays

Substances

  • Acrylamides
  • Contrast Media
  • Iodobenzoates
  • Polymers
  • N-isopropylacrylamide