Duboscic acid: a potent α-glucosidase inhibitor with an unprecedented triterpenoidal carbon skeleton from Duboscia macrocarpa

Pascal Wafo; Ramsay S T Kamdem; Zulfiqar Ali; Shazia Anjum; Shamsun Nahar Khan; Afshan Begum; Karsten Krohn; Berhanu M Abegaz; Bonaventure T Ngadjui; Muhammad Iqbal Choudhary

doi:10.1021/ol1026552

Duboscic acid: a potent α-glucosidase inhibitor with an unprecedented triterpenoidal carbon skeleton from Duboscia macrocarpa

Org Lett. 2010 Dec 17;12(24):5760-3. doi: 10.1021/ol1026552. Epub 2010 Nov 22.

Authors

Pascal Wafo¹, Ramsay S T Kamdem, Zulfiqar Ali, Shazia Anjum, Shamsun Nahar Khan, Afshan Begum, Karsten Krohn, Berhanu M Abegaz, Bonaventure T Ngadjui, Muhammad Iqbal Choudhary

Affiliation

¹ Department of Organic Chemistry, Higher Teachers' Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon. wafopascal@yahoo.fr

PMID: 21090700
DOI: 10.1021/ol1026552

Abstract

Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name "dubosane" is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Althaea / chemistry*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Glycoside Hydrolase Inhibitors*
Models, Molecular
Molecular Structure
Triterpenes / chemistry*
Triterpenes / pharmacology

Substances

Enzyme Inhibitors
Glycoside Hydrolase Inhibitors
Triterpenes
duboscic acid