[Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway]

Tanpakushitsu Kakusan Koso. 2009 Sep;54(12 Suppl):1676-83.
[Article in Japanese]
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Dihydroorotate Dehydrogenase
  • Drug Design*
  • Energy Metabolism
  • Fumarates
  • Nucleotides / biosynthesis*
  • Orotic Acid / analogs & derivatives
  • Oxidation-Reduction
  • Oxidoreductases Acting on CH-CH Group Donors / chemistry*
  • Oxidoreductases Acting on CH-CH Group Donors / physiology*
  • Oxonic Acid
  • Protein Conformation
  • Succinic Acid
  • Trypanocidal Agents*
  • Trypanosoma cruzi / growth & development
  • Trypanosoma cruzi / metabolism*

Substances

  • Dihydroorotate Dehydrogenase
  • Fumarates
  • Nucleotides
  • Trypanocidal Agents
  • 4,5-dihydroorotic acid
  • Oxonic Acid
  • Orotic Acid
  • fumaric acid
  • Succinic Acid
  • Oxidoreductases Acting on CH-CH Group Donors