Franklinolides A-C from an Australian marine sponge complex: phosphodiesters strongly enhance polyketide cytotoxicity

Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9904-6. doi: 10.1002/anie.201005883.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Australia
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Humans
  • Macrolides / pharmacology*
  • Organophosphates
  • Porifera
  • Pyrones / chemical synthesis*

Substances

  • Alkenes
  • Antineoplastic Agents
  • Macrolides
  • Organophosphates
  • Pyrones
  • franklinolide A
  • franklinolide B
  • franklinolide C