P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs

Org Biomol Chem. 2011 Feb 7;9(3):730-8. doi: 10.1039/c0ob00542h. Epub 2010 Nov 17.

Abstract

P(1),P(2)-Diimidazolyl derivatives of pyrophosphate and halomethylene-bis-phosphonates have been synthesized and characterized, and the mechanism of their formation was studied. These reagents enable synthesis of dinucleoside tetraphosphates and tetraphosphonates conveniently and in high yields.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cyclization
  • Dinucleoside Phosphates / chemical synthesis*
  • Diphosphates / chemistry*
  • Imidazoles / chemistry*
  • Molecular Structure
  • Organophosphonates / chemistry*

Substances

  • Dinucleoside Phosphates
  • Diphosphates
  • Imidazoles
  • Organophosphonates
  • imidazole