Demonstrating utility of pharmacogenetics in pediatric populations: methodological considerations

Clin Pharmacol Ther. 2010 Dec;88(6):757-9. doi: 10.1038/clpt.2010.242.

Abstract

Interpretable and meaningful pharmacogenetic data are dependent on accurate characterization of phenotypes. High-quality reports are critical, and important clinical data must not be omitted. Adequate funding to fully support dedicated program personnel is essential to meet this requirement because an "employee-driven" network that funds its surveillance clinicians is likely to be more effective than a voluntary surveillance model in capturing both adequate numbers of cases and well-characterized clinical data for rigorous phenotyping.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Child
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Pediatrics / methods*
  • Pharmacogenetics / methods*
  • Product Surveillance, Postmarketing / methods*