Advanced Parkinson's disease patients require for their care the participation of a multidisciplinary team. Particularly in the late stages of the disease, motor complications due both to medication and to progression of the disease, together with non-motor complications, add to the complexity of their management. Increasing age of the population will increase the incidence and the prevalence of the disease, with more patients reaching an advanced age and a more advanced stage of the disease, thus creating a public health problem for which we have to be prepared.