Skin function for human CD1a-reactive T cells

Nat Immunol. 2010 Dec;11(12):1079-80. doi: 10.1038/ni1210-1079.

Abstract

Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells.

Publication types

  • Comment
  • Review

MeSH terms

  • Antigens, CD1 / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Humans
  • Langerhans Cells / immunology*
  • Lymphocyte Activation / immunology*
  • Skin / cytology
  • Skin / immunology*

Substances

  • Antigens, CD1
  • CD1a antigen