Grand challenge commentary: Beyond discovery: probes that see, grab and poke

Joshua A Kritzer

doi:10.1038/nchembio.469

Grand challenge commentary: Beyond discovery: probes that see, grab and poke

Nat Chem Biol. 2010 Dec;6(12):868-70. doi: 10.1038/nchembio.469.

Author

Joshua A Kritzer¹

Affiliation

¹ Department of Chemistry, Tufts University, Medford, Massachusetts, USA. joshua.kritzer@tufts.edu

PMID: 21079592
DOI: 10.1038/nchembio.469

Abstract

Chemical biology is now able to discover molecules that manipulate virtually any biological target or process. It remains a grand challenge to leverage these molecules into useful probes that can be used to address unsolved problems in biology.

MeSH terms

Cell Biology
Drug Evaluation, Preclinical
Ligands
Protein Engineering
Protein Folding*
RNA, Small Interfering / chemistry
Small Molecule Libraries

Substances

Ligands
RNA, Small Interfering
Small Molecule Libraries