Subcutaneous phaeohyphomycosis caused by Cladophialophora boppii

Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):695-8. doi: 10.4103/0378-6323.72474.

Abstract

Subcutaneous phaeohyphomycosis is an infection of the skin and subcutaneous tissue, caused by dematiaceous fungi. An adult male presented with a history of multiple reddish nodules over the face and hands. Histopathological examination of the skin biopsies showed a dense granulomatous infiltrate of macrophages, containing intracytoplasmic basophilic bodies throughout the dermis. Gomori methenamine-silver stained sections revealed yeast cells within macrophages. Multiple cultures on Sabouraud's dextrose agar grew Cladophialophora boppii. The patient was treated with oral itraconazole for a year and the response monitored with dermal ultrasound. This is the first case report of subcutaneous phaeohyphomycosis caused by Cl. boppii in India.

Publication types

  • Case Reports

MeSH terms

  • Ascomycota / pathogenicity*
  • Dermatomycoses / diagnostic imaging*
  • Dermatomycoses / drug therapy
  • Humans
  • Itraconazole / therapeutic use
  • Male
  • Subcutaneous Tissue / diagnostic imaging*
  • Subcutaneous Tissue / drug effects
  • Subcutaneous Tissue / microbiology*
  • Ultrasonography
  • Young Adult

Substances

  • Itraconazole