The present study evaluated the anti-complement effects from organic solvent extracts of three varieties (Hwanggeumchal Sorghum, Chal Sorghum, and Heuin Sorghum) from Sorghum bicolor in classical pathway complement system. We have evaluated organic solvent extract from Sorghum bicolor varieties with regard to its anti-complement activity. Chal Sorghum ethyl acetate extract showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 38.7 μg/mL. This is the first report of anti-complement activity from Sorghum bicolor varieties.