Ovarian tumors are the most frequent lesions encountered by gynecologists. Ovarian carcinoma most often develops asymptomatically and until now no sufficient screening diagnostic methods have been developed, which is why various diagnostic methods are being tried concurrently to increase diagnostic sensitivity. The aim of this paper was to evaluate the compliance of the preoperative diagnoses with the results of histopathological examinations of ovarian tumors and to determine the usefulness of simultaneous application of gynecological, ultrasonographic, and Doppler examinations together with determination of CA-125 antigen in the diagnostic process of ovarian tumors. The study comprised a group of 250 women in reproductive age who were operated on for tumors of the ovary. Results of histopathological examinations were compared with the preoperative diagnosis based on the above-mentioned examinations and prognostic indicators: sensitivity, specificity, negative and positive prediction value as well as accuracy were determined. The results showed that combining the four diagnostic methods is a useful research panel in the preoperative diagnostic process of ovarian tumors and makes selecting the appropriate procedure and surgical treatment viable.