Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst

Chembiochem. 2010 Dec 10;11(18):2517-20. doi: 10.1002/cbic.201000422.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / enzymology*
  • Actinomycetales / genetics
  • Actinomycetales / metabolism
  • Amide Synthases / genetics
  • Amide Synthases / metabolism*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cyclization
  • Cysteamine / analogs & derivatives
  • Humans
  • Maytansine / analogs & derivatives*
  • Maytansine / chemistry
  • Maytansine / metabolism
  • Maytansine / pharmacology
  • Mutation

Substances

  • Antineoplastic Agents
  • seco-proansamitocin
  • Maytansine
  • Cysteamine
  • ansamitocins
  • Amide Synthases