Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

Ghulam M Maharvi; Albert O Edwards; Abdul H Fauq

doi:10.1016/j.tetlet.2010.09.139

Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

Tetrahedron Lett. 2010 Dec 8;51(49):6426-6428. doi: 10.1016/j.tetlet.2010.09.139.

Authors

Ghulam M Maharvi¹, Albert O Edwards, Abdul H Fauq

Affiliation

¹ Chemical Synthesis Core Facility, Mayo Clinic Jacksonville, FL 32246, USA.

Abstract

First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, C34:5n5.d(2), and three other unlabeled very long chain C30-32-containing polyunsaturated fatty acids are reported here. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation.

Abstract

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