Opposing contributions of polynucleotide phosphorylase and the membrane protein NlpI to biofilm formation by Salmonella enterica serovar Typhimurium

J Bacteriol. 2011 Jan;193(2):580-2. doi: 10.1128/JB.00905-10. Epub 2010 Nov 12.

Abstract

CsgD and cyclic-3',5'-di-guanylate are key regulators of biofilm formation in Salmonella enterica serovar Typhimurium. Our results show that polynucleotide phosphorylase and NlpI oppositely altered expression of CsgD. Polynucleotide phosphorylase and NlpI also had opposite effects on the expression of yjcC, which codes for a cyclic-3',5'-di-guanylate phosphodiesterase affecting CsgD expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3',5'-Cyclic-GMP Phosphodiesterases / biosynthesis
  • Bacterial Proteins / metabolism*
  • Biofilms / growth & development*
  • Lipoproteins / metabolism*
  • Membrane Proteins / metabolism*
  • Polyribonucleotide Nucleotidyltransferase / metabolism*
  • Salmonella typhimurium / physiology*
  • Trans-Activators / biosynthesis

Substances

  • Bacterial Proteins
  • Lipoproteins
  • Membrane Proteins
  • Trans-Activators
  • Polyribonucleotide Nucleotidyltransferase
  • 3',5'-Cyclic-GMP Phosphodiesterases