Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones

Chung-Kyu Ryu; Seung-Yon Lee; Na Young Kim; Jung An Hong; Joo Hee Yoon; Aram Kim

doi:10.1016/j.bmcl.2010.10.124

Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones

Bioorg Med Chem Lett. 2011 Jan 1;21(1):427-30. doi: 10.1016/j.bmcl.2010.10.124. Epub 2010 Oct 30.

Authors

Chung-Kyu Ryu¹, Seung-Yon Lee, Na Young Kim, Jung An Hong, Joo Hee Yoon, Aram Kim

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr

PMID: 21075635
DOI: 10.1016/j.bmcl.2010.10.124

Abstract

6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Carbazoles / chemical synthesis
Carbazoles / chemistry*
Carbazoles / pharmacology
Fungi / drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Antifungal Agents
Carbazoles