Mouse models of inherited cancer syndromes

Sohail Jahid; Steven Lipkin

doi:10.1016/j.hoc.2010.08.011

Mouse models of inherited cancer syndromes

Hematol Oncol Clin North Am. 2010 Dec;24(6):1205-28. doi: 10.1016/j.hoc.2010.08.011.

Authors

Sohail Jahid¹, Steven Lipkin

Affiliation

¹ Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.

Abstract

Animal models of cancer have been instrumental in understanding the progression and therapy of hereditary cancer syndromes. The ability to alter the genome of an individual mouse cell in both constitutive and inducible approaches has led to many novel insights into their human counterparts. In this review, knockout mouse models of inherited human cancer syndromes are presented and insights from the study of these models are highlighted.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal*
Genetic Predisposition to Disease / genetics*
Humans
Mice
Mice, Knockout
Mutation
Neoplastic Syndromes, Hereditary / genetics*

Abstract

Publication types

MeSH terms

Grants and funding