The prevalence of anemia and iron deficiency in IBD outpatients in Scandinavia

Scand J Gastroenterol. 2011 Mar;46(3):304-9. doi: 10.3109/00365521.2010.533382. Epub 2010 Nov 15.

Abstract

Objective: To evaluate the prevalence of anemia and iron deficiency (ID) among patients with inflammatory bowel disease (IBD) in the Scandinavian countries.

Material and methods: A cross-sectional study including 429 IBD patients from six centers in Denmark, Norway and Sweden. Patients were screened for anemia and ID. Each center included ~5% of their IBD cohort. Patients were consecutively seen in the outpatient clinic, regardless of disease activity and whether the visits were scheduled or not.

Results: The overall prevalence of anemia was 19% (95% CI: 16-23%). The prevalence was higher among patients with Crohn's disease than among patients with ulcerative colitis (p = 0.01). The etiology of anemia was as follows: iron deficiency anemia (20%), anemia of chronic disease (12%), and both conditions (68%). Less than 5% had folate acid or vitamin B12 deficiency. ID was found in 35% (CI: 31-40%) of the patients.

Conclusions: Anemia was present in every fifth IBD patient and ID in every third IBD patient.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anemia / blood
  • Anemia / epidemiology*
  • Anemia / etiology
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / epidemiology*
  • Anemia, Iron-Deficiency / etiology
  • C-Reactive Protein / analysis
  • Colitis, Ulcerative / blood
  • Colitis, Ulcerative / epidemiology
  • Colitis, Ulcerative / physiopathology
  • Crohn Disease / blood
  • Crohn Disease / epidemiology
  • Crohn Disease / physiopathology
  • Cross-Sectional Studies
  • Female
  • Ferritins / blood
  • Folic Acid / blood
  • Hemoglobins / analysis
  • Humans
  • Inflammatory Bowel Diseases / blood
  • Inflammatory Bowel Diseases / epidemiology*
  • Inflammatory Bowel Diseases / physiopathology
  • Iron / blood
  • Iron Deficiencies*
  • Male
  • Middle Aged
  • Prevalence
  • Scandinavian and Nordic Countries
  • Severity of Illness Index
  • Transferrin / analysis
  • Vitamin B 12 / blood

Substances

  • Hemoglobins
  • Transferrin
  • C-Reactive Protein
  • Ferritins
  • Folic Acid
  • Iron
  • Vitamin B 12