Zinc release of Zn₇-metallothionein-3 induces fibrillar type amyloid-β aggregates

Metallomics. 2010 Nov;2(11):741-4. doi: 10.1039/c0mt00027b. Epub 2010 Oct 21.

Abstract

The reactive oxygen species H₂O₂ promotes the Zn₇-metallothionein-3 induced Aβ(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn(2+) release, whereas amorphous aggregates are formed by addition of Zn(2+) to Aβ(40).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / drug effects
  • Amyloid / metabolism*
  • Cysteine / chemistry
  • Cysteine / metabolism
  • Metallothionein 3
  • Microscopy, Electron, Transmission
  • Nerve Tissue Proteins / metabolism*
  • Oxidation-Reduction
  • Reactive Oxygen Species*
  • Spectrometry, Mass, Electrospray Ionization
  • Zinc / metabolism*
  • Zinc / pharmacology

Substances

  • Amyloid
  • Metallothionein 3
  • Nerve Tissue Proteins
  • Reactive Oxygen Species
  • Zinc
  • Cysteine