Abstract
The reactive oxygen species H₂O₂ promotes the Zn₇-metallothionein-3 induced Aβ(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn(2+) release, whereas amorphous aggregates are formed by addition of Zn(2+) to Aβ(40).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid / drug effects
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Amyloid / metabolism*
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Cysteine / chemistry
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Cysteine / metabolism
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Metallothionein 3
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Microscopy, Electron, Transmission
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Nerve Tissue Proteins / metabolism*
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Oxidation-Reduction
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Reactive Oxygen Species*
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Spectrometry, Mass, Electrospray Ionization
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Zinc / metabolism*
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Zinc / pharmacology
Substances
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Amyloid
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Metallothionein 3
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Nerve Tissue Proteins
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Reactive Oxygen Species
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Zinc
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Cysteine