Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base

Marta E Alberto; Nino Russo

doi:10.1039/c0cc03605f

Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base

Chem Commun (Camb). 2011 Jan 21;47(3):887-9. doi: 10.1039/c0cc03605f. Epub 2010 Nov 11.

Authors

Marta E Alberto¹, Nino Russo

Affiliation

¹ Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy.

PMID: 21069245
DOI: 10.1039/c0cc03605f

Abstract

A detailed study on the reaction mechanism of trans-EE and trans-EE/Met Pt-containing anticancer drugs was carried out in order to rationalize the experimental kinetic data concerning the whole process leading to DNA platination.

MeSH terms

Antineoplastic Agents / pharmacology*
DNA / chemistry*
Guanine / chemistry*
Ligands
Methionine / chemistry*
Platinum Compounds / pharmacology*

Substances

Antineoplastic Agents
Ligands
Platinum Compounds
Guanine
DNA
Methionine