Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage

Fertil Steril. 2011 Mar 1;95(3):1149-51. doi: 10.1016/j.fertnstert.2010.10.005. Epub 2010 Nov 10.

Abstract

This study evaluated the effect of vitamin E supplementation to cryoprotective media on post-thaw motility and DNA integrity of normozoospermic and asthenozoospermic semen samples. The results of this study indicate that supplementation of vitamin E (5 mM) significantly improves the post-thaw motility and DNA integrity in normozoospermic and asthenozoospermic semen samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / pharmacology
  • Asthenozoospermia / therapy*
  • Cryopreservation*
  • Cryoprotective Agents / pharmacology
  • Culture Media / pharmacology
  • DNA Damage*
  • Freezing
  • Humans
  • Male
  • Reproductive Techniques, Assisted
  • Semen / cytology
  • Sperm Motility / drug effects*
  • Spermatozoa / drug effects*
  • Spermatozoa / physiology
  • Vitamin E / pharmacology*

Substances

  • Antioxidants
  • Cryoprotective Agents
  • Culture Media
  • Vitamin E