Abstract
Phosphine catalyzed enantioselective [3+2] cyclizations on 4-substituted 2,6-diarylidenecyclohexanones and 2,4-diarylidene-bicyclo[3.1.0]hexan-3-ones take place with high diastereo- and enantioselectivity levels. The process affords spirocyclic compounds with excellent stereochemical control of up to five stereogenic centres.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cyclization
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Cyclohexanones / chemical synthesis
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Cyclohexanones / chemistry*
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Hexanones / chemical synthesis
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Hexanones / chemistry*
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Models, Molecular
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Phosphines / chemistry*
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry*
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Stereoisomerism
Substances
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Cyclohexanones
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Hexanones
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Phosphines
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Spiro Compounds
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phosphine