Two novel alkaloids from the South China Sea marine sponge Dysidea sp

Shen Ren; Wei Ma; Tunhai Xu; Xiuping Lin; Hao Yin; Bin Yang; Xue-Feng Zhou; Xian-Wen Yang; Lijuan Long; Kyung Jin Lee; Qipin Gao; Yonghong Liu

doi:10.1038/ja.2010.134

Two novel alkaloids from the South China Sea marine sponge Dysidea sp

J Antibiot (Tokyo). 2010 Dec;63(12):699-701. doi: 10.1038/ja.2010.134. Epub 2010 Nov 10.

Authors

Shen Ren¹, Wei Ma, Tunhai Xu, Xiuping Lin, Hao Yin, Bin Yang, Xue-Feng Zhou, Xian-Wen Yang, Lijuan Long, Kyung Jin Lee, Qipin Gao, Yonghong Liu

Affiliation

¹ Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.

PMID: 21063424
DOI: 10.1038/ja.2010.134

Abstract

Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiomethylated imidazolinium unit as found in dysideanin A is very rarely encountered in nature.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
China
Dysidea / chemistry*
Imidazoles / chemistry
Imidazoles / isolation & purification
Imidazoles / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Piperidines / chemistry
Piperidines / isolation & purification
Piperidines / pharmacology
Spectrometry, Mass, Electrospray Ionization

Substances

Alkaloids
Anti-Bacterial Agents
Imidazoles
Piperidines