Apoptosis: opening PANdora's BoX

Christoph Peter; Sebastian Wesselborg; Kirsten Lauber

doi:10.1016/j.cub.2010.09.066

Apoptosis: opening PANdora's BoX

Curr Biol. 2010 Nov 9;20(21):R940-2. doi: 10.1016/j.cub.2010.09.066.

Authors

Christoph Peter¹, Sebastian Wesselborg, Kirsten Lauber

Affiliation

¹ Dept. of Internal Medicine I, Eberhard-Karls-University of Tuebingen, Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.

PMID: 21056838
DOI: 10.1016/j.cub.2010.09.066

Abstract

Extracellular nucleotides have been reported to act as a 'find-me' signal in the context of phagocyte recruitment by apoptotically dying cells. A new study now examines the mechanisms of nucleotide release during apoptosis and describes the hemichannel-forming protein pannexin 1 as a crucial player in this scenario.

MeSH terms

Adenosine Triphosphate / metabolism*
Apoptosis / drug effects
Apoptosis / physiology*
Cell Membrane Permeability / physiology
Connexins / physiology*
Humans
Jurkat Cells
Nerve Tissue Proteins / physiology*
Patch-Clamp Techniques
Phagocytes / physiology
Phagocytosis / drug effects
Uridine Triphosphate / metabolism*

Substances

Connexins
Nerve Tissue Proteins
PANX1 protein, human
Adenosine Triphosphate
Uridine Triphosphate