Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-galactose-injected mice

Liu Li; Jiong Ding; Charles Marshall; Junying Gao; Gang Hu; Ming Xiao

doi:10.1016/j.bbr.2010.10.032

Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-galactose-injected mice

Behav Brain Res. 2011 Feb 2;217(1):244-7. doi: 10.1016/j.bbr.2010.10.032. Epub 2010 Nov 3.

Authors

Liu Li¹, Jiong Ding, Charles Marshall, Junying Gao, Gang Hu, Ming Xiao

Affiliation

¹ Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu Province 210029, PR China.

PMID: 21055424
DOI: 10.1016/j.bbr.2010.10.032

Abstract

There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of D-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / psychology*
Animals
Disease Models, Animal
Female
Galactose*
Maze Learning*
Mice
Mice, Inbred ICR
Ovariectomy*
Practice, Psychological*

Substances

Galactose