Industrial-scale manufacturing of a possible oligonucleotide cargo CPP-based drug

Methods Mol Biol. 2011:683:505-24. doi: 10.1007/978-1-60761-919-2_36.

Abstract

This chapter describes the manufacturing process to a certain level for a possible oligonucleotide cargo and a peptide API in a multi-kilogram scale from a manufacture's point of view. In the concluding remarks, possible conjugation methods will be discussed from an industrial-scale perspective.

MeSH terms

  • Cell-Penetrating Peptides / chemical synthesis*
  • Cell-Penetrating Peptides / chemistry
  • Cell-Penetrating Peptides / isolation & purification
  • Cell-Penetrating Peptides / metabolism*
  • Chromatography, High Pressure Liquid
  • Chromatography, Reverse-Phase
  • Drug Carriers / chemical synthesis*
  • Drug Carriers / chemistry
  • Drug Carriers / isolation & purification
  • Drug Carriers / metabolism*
  • Drug Industry*
  • Fluorenes / chemistry
  • Indicators and Reagents / chemistry
  • Oligonucleotides / chemical synthesis*
  • Oligonucleotides / chemistry
  • Oligonucleotides / isolation & purification
  • Oligonucleotides / metabolism*
  • Resins, Synthetic / chemistry
  • Solvents / chemistry

Substances

  • 9-fluorenylmethoxycarbonyl
  • Cell-Penetrating Peptides
  • Drug Carriers
  • Fluorenes
  • Indicators and Reagents
  • Oligonucleotides
  • Resins, Synthetic
  • Solvents