SAR studies of gymnasterkoreayne derivatives with cancer chemopreventive activities

Dongyun Shin; Jung-Eun Yang; Saet Byoul Lee; Chu Won Nho

doi:10.1016/j.bmcl.2010.07.066

SAR studies of gymnasterkoreayne derivatives with cancer chemopreventive activities

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7549-52. doi: 10.1016/j.bmcl.2010.07.066. Epub 2010 Jul 21.

Authors

Dongyun Shin¹, Jung-Eun Yang, Saet Byoul Lee, Chu Won Nho

Affiliation

¹ Life/Health Division, Korea Institute of Science and Technology (KIST), Seongbuk-Gu, Seoul, Republic of Korea. dyshin21@kist.re.kr

PMID: 21050753
DOI: 10.1016/j.bmcl.2010.07.066

Abstract

We synthesized diyne triols based on gymnasterkoreayne and evaluated their cancer chemopreventive activities in terms of the chemopreventive index (CI) to reveal the structure-activity relationship, and discovered more active compounds than natural diynes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylene / analogs & derivatives*
Acetylene / chemical synthesis
Acetylene / chemistry
Acetylene / therapeutic use
Anticarcinogenic Agents / chemical synthesis
Anticarcinogenic Agents / chemistry*
Anticarcinogenic Agents / therapeutic use
Enediynes / chemical synthesis
Enediynes / chemistry*
Enediynes / therapeutic use
Humans
Structure-Activity Relationship

Substances

Anticarcinogenic Agents
Enediynes
gymnasterkoreaside B
gymnasterkoreayne G
Acetylene