The aim of this work was to identify all papers already published on the nutritional supplement known as multimixture (MM) in journals with high level of scientific rigor and to evaluate the effectiveness of this product as a food supplement. The methodology was based on searching at Medline and Scielo databases, without limit of date, using the keyword multimixture. Thirty one articles were analyzed. Because of the small portion that is recommended for daily consumption, the MM cannot be considered an important source of energy, protein and minerals. Its high proportion of magnesium and/or calcium can impair the absorption of iron. Its use increases the fiber content of the diet, which can reduce the absorption of nutrients, which is not interesting in the case of malnourished children. Its high amount of phytate seems to be no problem because the prior treatment to which the bran is submitted reduces the chelating power of this compound. The possibility of poisoning by cyanide come from the cassava leaf is not discarded. Regarding the ability to promote the nutritional state, 12 out of 15 studies concluded its ineffectiveness. Considering risks and benefits and the available evidence in the literature, is not justified the use of MM as a strategy for prevention and control of malnutrition.