This report presents a case of nodular colloid degeneration in a 76-year-old man with a solitary facial lesion. The skin lesion was a yellowish indurated plaque on the left mandibular area. Histopathologic examination revealed the amorphous colloid material in the upper dermis. The Congo red stain was negative, no birefringence was observed under polarized light, and elastic stain showed positivity in both the colloid and the surrounding fibers. To the best of our knowledge, nodular colloid degeneration is a rare entity and has only been reported in published literature a few times in the last 8 decades.