Abstract
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Aged
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Aged, 80 and over
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Aging / genetics*
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Aging / pathology
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Aging / psychology
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Alleles
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Alzheimer Disease / diagnosis
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Alzheimer Disease / pathology
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Amyloid beta-Protein Precursor / genetics*
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Animals
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Apolipoproteins E / genetics*
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Disease Models, Animal
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Genetic Counseling
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Genetic Predisposition to Disease
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Genetic Testing
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Genotype
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Humans
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Presenilin-1 / genetics*
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Presenilin-2 / genetics*
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Prevalence
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Risk Factors
Substances
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Amyloid beta-Protein Precursor
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Apolipoproteins E
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Presenilin-1
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Presenilin-2