Extinction of Xist improves cloning

Peter Dennis Tonge; Andras Nagy

doi:10.1016/j.stem.2010.10.003

Extinction of Xist improves cloning

Cell Stem Cell. 2010 Nov 5;7(5):550-2. doi: 10.1016/j.stem.2010.10.003.

Authors

Peter Dennis Tonge¹, Andras Nagy

Affiliation

¹ Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

PMID: 21040894
DOI: 10.1016/j.stem.2010.10.003

Abstract

Mammalian cloning by somatic cell nuclear transfer is a notoriously inefficient process with a low birth rate. Recently in Science, Inoue et al. (2010) report that somatic cell nuclear transfer fails to regulate Xist expression from the X chromosome.

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