Allosteric trumps covalent in the control of glycogen synthesis

Matthew J Brady

doi:10.1016/j.cmet.2010.10.008

Allosteric trumps covalent in the control of glycogen synthesis

Cell Metab. 2010 Nov 3;12(5):428-30. doi: 10.1016/j.cmet.2010.10.008.

Author

Matthew J Brady¹

Affiliation

¹ Department of Medicine, Kovler Diabetes Center, University of Chicago, IL 60637, USA. mbrady@medicine.bsd.uchicago.edu

PMID: 21035754
DOI: 10.1016/j.cmet.2010.10.008

Abstract

Glycogen metabolism serves as a critical regulator of energy storage and maintenance of blood glucose levels in a physiological range. In this issue of Cell Metabolism, Bouskila et al. (2010) unexpectedly find that skeletal muscle glycogen accumulation is principally controlled by the allosteric activation of glycogen synthase, opening new avenues for investigation.

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