Immunologic basis of vaccine vectors

Immunity. 2010 Oct 29;33(4):504-15. doi: 10.1016/j.immuni.2010.10.004.

Abstract

Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer, autoimmune diseases and allergy have utilized a variety of heterologous expression systems, including viral and bacterial vectors, as well as DNA and RNA constructs. This review explores the immunologic rationale and provides an update of insights obtained from preclinical and clinical studies of such vaccines.

Publication types

  • Review

MeSH terms

  • Adenoviridae / genetics
  • Animals
  • Genetic Vectors*
  • Humans
  • Poxviridae / genetics
  • T-Lymphocytes, Cytotoxic / immunology
  • Vaccination / veterinary
  • Vaccines, DNA / immunology*
  • Vaccines, Synthetic / immunology*

Substances

  • Vaccines, DNA
  • Vaccines, Synthetic