Abstract
Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na(+) and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na(+), K(+)-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA α₁-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-β, PKC-ζ), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.
MeSH terms
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Adenylyl Cyclases / metabolism
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Angiotensin II / metabolism*
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Animals
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Biological Transport
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Dopamine / metabolism*
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Humans
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Hypertension / metabolism
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Hypertension / physiopathology
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Kidney Tubules, Proximal / metabolism*
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Membrane Proteins / metabolism
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PDZ Domains
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Phosphorylation
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Protein Isoforms / metabolism
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Protein Kinase C / metabolism
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Receptor Cross-Talk / physiology
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Receptors, Angiotensin / metabolism
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Receptors, Dopamine / metabolism
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Signal Transduction / physiology
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Sodium-Potassium-Exchanging ATPase* / metabolism
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Tight Junction Proteins
Substances
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Membrane Proteins
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PATJ protein, human
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Protein Isoforms
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Receptors, Angiotensin
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Receptors, Dopamine
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Tight Junction Proteins
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Angiotensin II
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Protein Kinase C
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Adenylyl Cyclases
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Sodium-Potassium-Exchanging ATPase
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Dopamine