Abstract
Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC(50) values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC(50) values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N(ω)-nitro-L-arginine methyl ester.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification*
-
Anti-Inflammatory Agents / pharmacology*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology*
-
Drug Screening Assays, Antitumor
-
Fruiting Bodies, Fungal / chemistry
-
Humans
-
Inhibitory Concentration 50
-
Molecular Structure
-
NG-Nitroarginine Methyl Ester / pharmacology
-
Nitric Oxide Synthase / antagonists & inhibitors
-
Nuclear Magnetic Resonance, Biomolecular
-
Polyporaceae / chemistry*
-
Stereoisomerism
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology*
Substances
-
Anti-Inflammatory Agents
-
Antineoplastic Agents
-
Triterpenes
-
Nitric Oxide Synthase
-
NG-Nitroarginine Methyl Ester