Our aim was to find a formulation for pyramidon suppositories in which the physicochemical compatibility of the active substance with the excipient to be the highest. Fatty and hydrosoluble excipients were studied. Following up in time the quality of the obtained preparation, it was concluded that the fatty substances are preferable, the suppositories with glycero-gelatinous mass being more stable by an one hour freezing and two hours freeze drying.