Abstract
Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cytokines / metabolism
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DNA Methylation
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Epigenesis, Genetic
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Gene Expression Regulation, Neoplastic
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Hodgkin Disease / genetics*
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Hodgkin Disease / metabolism
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Humans
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Models, Biological
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NF-kappa B / metabolism
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Proto-Oncogenes / genetics*
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Receptor, Macrophage Colony-Stimulating Factor / metabolism
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Terminal Repeat Sequences
Substances
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Cytokines
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NF-kappa B
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Receptor, Macrophage Colony-Stimulating Factor